Iron: benefits and
risks
BY JOAQUIN ORAMAS
IRON deficiency is one of the most extensive
nutritional problems in the world, especially in
developing countries and among low-income
populations, although it is present in every
country.
Thus, it is worth repeating that from an early
age to old age, any deficiency should be treated
with priority.
The reduction of iron intake in a daily diet
leads to a gradual reduction in its levels in the
body, with the consequent appearance of anemia
called ferropexia. If this condition is not reversed,
iron deficiency anemia may compromise psycho-motor
development and cognitive abilities during growth
stages.
Iron in the body is found in diverse elements or
substances (compounds) where hemoglobin possesses
between 65 and 705 of the total. It is stored in two
ways: ferritin and hemosiderin. In the first
instance, a reduction in deposits occurs, not yet
associated with clinical symptoms of anemia, where
the body increases absorption of this element if its
supply through eating is adequate.
If not, the shortage is accentuated with a
decrease in diverse compounds responsible for its
transport, showing itself only through biochemical
determinations.
Finally, when the iron deficit gives rise to a
decrease in hemoglobin production, ferropectic
anemia occurs, principally manifested through
paleness of the skin and mucous membranes; unusual
tiredness; lack of appetite and decreased abilities
or performance in school or work. The body needs
iron to generate hemoglobin, the protein complex
that transports oxygen through the blood, and to
build enzymes like cytochromes, which act as
catalysts in order to produce energy in cells.
Iron is so important that the human body has
developed strategies to conserve it. Excess iron is
enclosed by a protein called ferritin and stored in
bone marrow, the liver and the spleen. When tired,
the body resorts to this reserve.
Likewise, except when we bleed, iron is only
eliminated from the body in miniscule quantities.
That is why women are at risk of anemia during
menstruation. Men are most at risk for iron overload,
which can lead to diabetes, arthritis, cancer of the
liver, heart problems and other organ disorders.
Experts are concerned about the well-known theory
that iron causes oxygen damage to tissues and organs,
generating some chemical products that are extremely
radioactive, called free radicals.
Test tube experiments have shown that this
mineral is a powerful catalyst, promoting chemical
reactions that snatch electrons from one molecule
and provide it to another.
This ability makes it a valuable component of
enzymes. In turn, if the iron takes over the body’s
electrons at random, free radicals produced could
harm vital proteins, lipids and DNA, disintegrating
cells or making them cancerous. It is reasonable to
believe that they could cause oxygen damage to the
body. Of course, it is very improbable that they
couldn’t, affirms Lawrence Loeb, director of the
Joseph Gottstein Cancer Laboratory at the University
of Washington in Seattle.
Other U.S. scientists acknowledge that there are
good theoretical reasons to research the
relationship between iron and cancer, which is why
they are now reevaluating the preponderance of iron
deficiency and an overabundance of the mineral in
food.
Iron is a widely distributed element in nature,
and carries out vital functions. The most important
is the transport of oxygen from breathing to
different body tissues. That function is carried out
thanks to its combination with proteins to form
hemoglobin as part of the blood cells that transport
oxygen. It is also a component of myoglobin, which
gives our muscles their red color and stores oxygen
in them.
For more information:
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